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Cell-substrate adhesion characteristics control cell spanning. (a) Representative microscopy images for fibroblasts adhered to a soft substrate, stimulated with CN03 (RhoA activator), <t>Y27632</t> (ROCK inhibitor), PF228 (Focal adhesion kinase inhibitor), and MMC (DNA crosslinking). (b) Cell length for the distinct modulators and (c) FSD compared to the fibroblasts (dash-dotted reference line indicates the median value). (d) Relationship between probability of spanning cells and cylinder diameter for the selected cell types. (e) Correlation between cell length and probability of cells spanning. (f) Correlation between FSD and probability of cells spanning. In red, allometric fit, given by y = a x b . (g, left) Schematic representation of the boundary conditions ( U, UR indicating translational and rotational degrees of freedom respectively) and material properties of the FE model representing an individual cell with two adhesion morphologies (C1 = fully adherent, circular morphology, C2 = large FSD, polar morphology) attached to cylindrical surfaces with Ø = 100 and 1000 μm. (g, middle) Resulting cell displacement according to the cell adhesion morphology (C1, C2) on a cylinder with Ø = 100 μm and (g, right) on a cylinder with Ø = 1000 μm in isometric view (top row) and front view (bottom row). Vector plot is combined with deformed shape to better visualize the direction and magnitude of the displacement. Statistical significance via Mann-Whitney test (two sided) with Bonferroni correction, ∗p < 0.05. N ≥ 60 cells/cell type for FA and morphological analysis. N ≥ 3 GeoChips/cell type for a total of N ≥ 12 half-cylinders/condition. 1 donor/cell type. Scale bar 50 μm.
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Cell-substrate adhesion characteristics control cell spanning. (a) Representative microscopy images for fibroblasts adhered to a soft substrate, stimulated with CN03 (RhoA activator), <t>Y27632</t> (ROCK inhibitor), PF228 (Focal adhesion kinase inhibitor), and MMC (DNA crosslinking). (b) Cell length for the distinct modulators and (c) FSD compared to the fibroblasts (dash-dotted reference line indicates the median value). (d) Relationship between probability of spanning cells and cylinder diameter for the selected cell types. (e) Correlation between cell length and probability of cells spanning. (f) Correlation between FSD and probability of cells spanning. In red, allometric fit, given by y = a x b . (g, left) Schematic representation of the boundary conditions ( U, UR indicating translational and rotational degrees of freedom respectively) and material properties of the FE model representing an individual cell with two adhesion morphologies (C1 = fully adherent, circular morphology, C2 = large FSD, polar morphology) attached to cylindrical surfaces with Ø = 100 and 1000 μm. (g, middle) Resulting cell displacement according to the cell adhesion morphology (C1, C2) on a cylinder with Ø = 100 μm and (g, right) on a cylinder with Ø = 1000 μm in isometric view (top row) and front view (bottom row). Vector plot is combined with deformed shape to better visualize the direction and magnitude of the displacement. Statistical significance via Mann-Whitney test (two sided) with Bonferroni correction, ∗p < 0.05. N ≥ 60 cells/cell type for FA and morphological analysis. N ≥ 3 GeoChips/cell type for a total of N ≥ 12 half-cylinders/condition. 1 donor/cell type. Scale bar 50 μm.
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Cell-substrate adhesion characteristics control cell spanning. (a) Representative microscopy images for fibroblasts adhered to a soft substrate, stimulated with CN03 (RhoA activator), <t>Y27632</t> (ROCK inhibitor), PF228 (Focal adhesion kinase inhibitor), and MMC (DNA crosslinking). (b) Cell length for the distinct modulators and (c) FSD compared to the fibroblasts (dash-dotted reference line indicates the median value). (d) Relationship between probability of spanning cells and cylinder diameter for the selected cell types. (e) Correlation between cell length and probability of cells spanning. (f) Correlation between FSD and probability of cells spanning. In red, allometric fit, given by y = a x b . (g, left) Schematic representation of the boundary conditions ( U, UR indicating translational and rotational degrees of freedom respectively) and material properties of the FE model representing an individual cell with two adhesion morphologies (C1 = fully adherent, circular morphology, C2 = large FSD, polar morphology) attached to cylindrical surfaces with Ø = 100 and 1000 μm. (g, middle) Resulting cell displacement according to the cell adhesion morphology (C1, C2) on a cylinder with Ø = 100 μm and (g, right) on a cylinder with Ø = 1000 μm in isometric view (top row) and front view (bottom row). Vector plot is combined with deformed shape to better visualize the direction and magnitude of the displacement. Statistical significance via Mann-Whitney test (two sided) with Bonferroni correction, ∗p < 0.05. N ≥ 60 cells/cell type for FA and morphological analysis. N ≥ 3 GeoChips/cell type for a total of N ≥ 12 half-cylinders/condition. 1 donor/cell type. Scale bar 50 μm.
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Cell-substrate adhesion characteristics control cell spanning. (a) Representative microscopy images for fibroblasts adhered to a soft substrate, stimulated with CN03 (RhoA activator), <t>Y27632</t> (ROCK inhibitor), PF228 (Focal adhesion kinase inhibitor), and MMC (DNA crosslinking). (b) Cell length for the distinct modulators and (c) FSD compared to the fibroblasts (dash-dotted reference line indicates the median value). (d) Relationship between probability of spanning cells and cylinder diameter for the selected cell types. (e) Correlation between cell length and probability of cells spanning. (f) Correlation between FSD and probability of cells spanning. In red, allometric fit, given by y = a x b . (g, left) Schematic representation of the boundary conditions ( U, UR indicating translational and rotational degrees of freedom respectively) and material properties of the FE model representing an individual cell with two adhesion morphologies (C1 = fully adherent, circular morphology, C2 = large FSD, polar morphology) attached to cylindrical surfaces with Ø = 100 and 1000 μm. (g, middle) Resulting cell displacement according to the cell adhesion morphology (C1, C2) on a cylinder with Ø = 100 μm and (g, right) on a cylinder with Ø = 1000 μm in isometric view (top row) and front view (bottom row). Vector plot is combined with deformed shape to better visualize the direction and magnitude of the displacement. Statistical significance via Mann-Whitney test (two sided) with Bonferroni correction, ∗p < 0.05. N ≥ 60 cells/cell type for FA and morphological analysis. N ≥ 3 GeoChips/cell type for a total of N ≥ 12 half-cylinders/condition. 1 donor/cell type. Scale bar 50 μm.
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Cell-substrate adhesion characteristics control cell spanning. (a) Representative microscopy images for fibroblasts adhered to a soft substrate, stimulated with CN03 (RhoA activator), <t>Y27632</t> (ROCK inhibitor), PF228 (Focal adhesion kinase inhibitor), and MMC (DNA crosslinking). (b) Cell length for the distinct modulators and (c) FSD compared to the fibroblasts (dash-dotted reference line indicates the median value). (d) Relationship between probability of spanning cells and cylinder diameter for the selected cell types. (e) Correlation between cell length and probability of cells spanning. (f) Correlation between FSD and probability of cells spanning. In red, allometric fit, given by y = a x b . (g, left) Schematic representation of the boundary conditions ( U, UR indicating translational and rotational degrees of freedom respectively) and material properties of the FE model representing an individual cell with two adhesion morphologies (C1 = fully adherent, circular morphology, C2 = large FSD, polar morphology) attached to cylindrical surfaces with Ø = 100 and 1000 μm. (g, middle) Resulting cell displacement according to the cell adhesion morphology (C1, C2) on a cylinder with Ø = 100 μm and (g, right) on a cylinder with Ø = 1000 μm in isometric view (top row) and front view (bottom row). Vector plot is combined with deformed shape to better visualize the direction and magnitude of the displacement. Statistical significance via Mann-Whitney test (two sided) with Bonferroni correction, ∗p < 0.05. N ≥ 60 cells/cell type for FA and morphological analysis. N ≥ 3 GeoChips/cell type for a total of N ≥ 12 half-cylinders/condition. 1 donor/cell type. Scale bar 50 μm.
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Cell-substrate adhesion characteristics control cell spanning. (a) Representative microscopy images for fibroblasts adhered to a soft substrate, stimulated with CN03 (RhoA activator), Y27632 (ROCK inhibitor), PF228 (Focal adhesion kinase inhibitor), and MMC (DNA crosslinking). (b) Cell length for the distinct modulators and (c) FSD compared to the fibroblasts (dash-dotted reference line indicates the median value). (d) Relationship between probability of spanning cells and cylinder diameter for the selected cell types. (e) Correlation between cell length and probability of cells spanning. (f) Correlation between FSD and probability of cells spanning. In red, allometric fit, given by y = a x b . (g, left) Schematic representation of the boundary conditions ( U, UR indicating translational and rotational degrees of freedom respectively) and material properties of the FE model representing an individual cell with two adhesion morphologies (C1 = fully adherent, circular morphology, C2 = large FSD, polar morphology) attached to cylindrical surfaces with Ø = 100 and 1000 μm. (g, middle) Resulting cell displacement according to the cell adhesion morphology (C1, C2) on a cylinder with Ø = 100 μm and (g, right) on a cylinder with Ø = 1000 μm in isometric view (top row) and front view (bottom row). Vector plot is combined with deformed shape to better visualize the direction and magnitude of the displacement. Statistical significance via Mann-Whitney test (two sided) with Bonferroni correction, ∗p < 0.05. N ≥ 60 cells/cell type for FA and morphological analysis. N ≥ 3 GeoChips/cell type for a total of N ≥ 12 half-cylinders/condition. 1 donor/cell type. Scale bar 50 μm.

Journal: Bioactive Materials

Article Title: Cell type-specific response to curvature controls tissue growth dynamics in biomaterial pores

doi: 10.1016/j.bioactmat.2026.02.005

Figure Lengend Snippet: Cell-substrate adhesion characteristics control cell spanning. (a) Representative microscopy images for fibroblasts adhered to a soft substrate, stimulated with CN03 (RhoA activator), Y27632 (ROCK inhibitor), PF228 (Focal adhesion kinase inhibitor), and MMC (DNA crosslinking). (b) Cell length for the distinct modulators and (c) FSD compared to the fibroblasts (dash-dotted reference line indicates the median value). (d) Relationship between probability of spanning cells and cylinder diameter for the selected cell types. (e) Correlation between cell length and probability of cells spanning. (f) Correlation between FSD and probability of cells spanning. In red, allometric fit, given by y = a x b . (g, left) Schematic representation of the boundary conditions ( U, UR indicating translational and rotational degrees of freedom respectively) and material properties of the FE model representing an individual cell with two adhesion morphologies (C1 = fully adherent, circular morphology, C2 = large FSD, polar morphology) attached to cylindrical surfaces with Ø = 100 and 1000 μm. (g, middle) Resulting cell displacement according to the cell adhesion morphology (C1, C2) on a cylinder with Ø = 100 μm and (g, right) on a cylinder with Ø = 1000 μm in isometric view (top row) and front view (bottom row). Vector plot is combined with deformed shape to better visualize the direction and magnitude of the displacement. Statistical significance via Mann-Whitney test (two sided) with Bonferroni correction, ∗p < 0.05. N ≥ 60 cells/cell type for FA and morphological analysis. N ≥ 3 GeoChips/cell type for a total of N ≥ 12 half-cylinders/condition. 1 donor/cell type. Scale bar 50 μm.

Article Snippet: Y27632 (13624, Cell Signaling Technology, Inc.) was supplemented to the medium at a concentration of 10 μM, CN03 (Rho Activator II, Cytoskeleton, Inc.) was used at a concentration of 5 μg/ml, and PF228 (PZ0117, Sigma-Aldrich) was supplemented at a concentration of 100 μM.

Techniques: Control, Microscopy, Plasmid Preparation, MANN-WHITNEY